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Figure 19 | Journal of Neuroinflammation

Figure 19

From: Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models

Figure 19

Quantitation of microglial burden in the cortex of TgSwDI mice. Microglial burden was analyzed semiquantitatively on a scale of 0 to 4. Representative brain sections of both (A) vehicle control and (B) pBri-treated Tg mice immunostained with CD45 from the cortex. (C) Bar graph of microglia semiquantitative analysis for the cortex of vehicle control and pBri-vaccinated mice. On average there was a 42% reduction in the areas occupied by CD45 immunoreactivity accounting for microgliosis (*P = 0.027 by an unpaired one-tailed t-test). Tg, transgenic.

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Journal of Neuroinflammation

ISSN: 1742-2094