Figure 7
Quantitation of amyloid burden in the hippocampus of 3xTg mice. Representative brain sections of both (A) vehicle control and (B) pBri-treated Tg mice immunostained with anti-Aβ antibodies 4G8 and 6E10 from the hippocampus. (C) Bar graph of hippocampus burden calculated using stereology for the hippocampus of vehicle control and pBri-vaccinated 3xTg mice. On average there was a 71% reduction in the areas occupied by 4G8/6E10 immunoreactivity accounting for precipitated amyloid (***P = 0.0006 by an unpaired two-tailed t-test). Tg, transgenic.