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Table 2 MCSF results following sham injury and cFPI brain injury

From: Traumatic axonal injury in the mouse is accompanied by a dynamic inflammatory response, astroglial reactivity and complex behavioral changes

PARAMETERS

Sham Trial 1

cFPI Trial 1

Sham Trial 2

cFPI Trial 2

LATENCY (sec)

    

LEAVE CENTRE

78.3 ± 50.5

150 ± 285.8

5.2 ± 3.9

12 ± 13.5

DCR

217.9 ± 188

301.1 ± 299.5

109 ± 19.9

73.3 ± 67.5

SLOPE ENTRANCE

164.4 ± 111.5

261.3 ± 287.6

89.5 ± 98.8

76.5 ± 131.4

SLOPE

525.8 ± 425.2

650 ± 390.7

577.9 ± 495.4

627.1 ± 509.2

BRIGDE

639.9 ± 497.6

768.6 ± 421.8

682.1 ± 485.8

689.3 ± 516

HURDLE

179.2 ± 154

267.4 ± 292

58.4 ± 64.5

106.4 ± 98.9

CENTRAL CIRCLE

31 ± 45.5

55.7 ± 53.7

130.1 ± 109.3

87.9 ± 86.9

REARING

59.7 ± 40.4

49.9 ± 35.7

65.8 ± 70.8

34.8 ± 45.3

GROOMING

363.2 ± 347.3

280.7 ± 360.2

570.7 ± 413.9

547.7 ± 495.9

FREQUENCY

    

CENTRE

24.1 ± 5.7

17.4 ± 7 *

36.6 ± 6.4

29.4 ± 9.4*

DCR

10.5 ± 4.4

8.1 ± 4.4

16.1 ± 6.2

16.5 ± 5.8

SLOPE ENTRANCE

8.4 ± 2.0

7.3 ± 3.5

10.5 ± 2.1

10.1 ± 3.6

SLOPE

2.7 ± 1.8

2.1 ± 2

3.5 ± 3.1

2.3 ± 2.3

BRIDGE

3.7 ± 3.5

3.1 ± 3.4

2.7 ± 2.6

2.8 ± 2.8

HURDLE

10 ± 2.9

11.7 ± 5.2

13.1 ± 3

11.1 ± 4.3

CENTRAL CIRCLE

10.5 ± 4.4

13.8 ± 7

8.9 ± 4.2

8.9 ± 4.6

TOTAL CORRIDORS

33.3 ± 6.9

28.1 ± 10.1

58.8 ± 6.4

51.1 ± 12.7 *

REARING

63 ± 23

81.8 ± 20.7

62.5 ± 24

60.1 ± 28.5

GROOMING

1.9 ± 1.1

2.7 ± 1.5

1.2 ± 0.8

0.9 ± 0.9

DURATION (sec)

    

CENTRE

226.3 ± 53.3

345.2 ± 234

127.7 ± 21.5

139.2±13

DCR

166.6 ± 72.2

149.2 ± 99.2

235.9 ± 90

334.2 ± 160.1

SLOPE ENTRANCE

51.7 ± 10

44.8 ± 23.6

59.5 ± 21.7

57.1 ± 25.7

SLOPE

70.7 ± 50

57.8 ± 57.9

45.3 ± 41.6

50.3 ± 47.7

BRIGDE

56.8 ± 55.7

47.7 ± 47.1

39.6 ± 45.2

42.2 ± 47.5

HURDLE

175.2 ± 61.1

154.6 ± 67.3

178.8 ± 53.8

138.1 ± 59.2

CENTRAL CIRCLE

13.2 ± 20.7

13.9 ± 21.5

4.4 ± 2.6

4.4 ± 2.3

TOTAL CORRIDORS

401.5 ± 68

359.7 ± 120.1

464.3 ± 98.8

399.9 ± 91.7

GROOMING

12.6 ± 9.2

29.5 ± 30.8

9.3 ± 9.9

5.8 ± 7.2

DURATION/FREQUENCY

    

DCR

16 ± 4.3

17.4 ± 8

15 ± 3.7

20.7 ± 8.5

SLOPE ENTRANCE

6.4 ± 1.7

6.3 ± 3.4

5.7 ± 1.7

5.5 ± 2

SLOPE

20.5 ± 15

23.7 ± 22.3

9.1 ± 8.1

22.6 ± 38.4

BRIDGE

9.4 ± 8.7

11.8 ± 11.1

8.4 ± 7.9

8.8 ± 8.7

HURDLE

17.7 ± 4.8

12.6 ± 4.4 *

13.9 ± 3.6

12.7 ± 3.8

TOTAL CORRIDORS

12.7 ± 3.4

12.6 ± 5.1

8.1 ± 2.4

8.1 ± 2.3

ACTIVITY MEASURES

    

TOTAL ACTIVITY

105 ± 19.8

95 ± 25.6

157.7 ± 19.3

137.2 ± 31.9 *

DISTANCE MOVED (cm)

4907 ± 933

5185 ± 1074.5

4865 ± 745.7

4644 ± 1204

VELOCITY ARENA (cm/s)

5 ± 0.7

5.5 ± 0.8

5.1 ± 0.7

4.7 ± 1.1

VELOCITY CENTRAL CIRCLE (cm/s)

14.8 ± 4.1

15.6 ± 5.4

22.8 ± 3.7

20.5 ± 8.9

HEAD DIPS

16.5 ± 7.7

9.8 ± 7.4

13 ± 4.6

13.1 ± 8.1

  1. Behavioral parameters of sham-injured and cFPI brain-injured mice in the multivariate concentric square field test during the first and second trial at post-injury day 2 and 9, respectively. Values represent mean ± standard deviation. Sham n = 10, cFPI n = 16. *P<0.05 compared to sham-injured mice analyzed by Kruskal-Wallis test and Mann–Whitney U test.
  2. cFPI: Central fluid percussion injury; DCR: Dark corner room.