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Table 1 Striatal monoamine levels (pM/mg tissue)

From: DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson’s disease

 

Dopamine

DOPAC

HVA

Saline

   

DAP12+/+(n = 5)

86.1 ± 5.2

13.8 ± 1.7

8.9 ± 1.5

DAP12KI (n = 3)

81.9 ± 10.7

14.6 ± 2.2

9.4 ± 1.1

MPTP

   

DAP12+/+(n = 5)

5.6 ± 0.9

4.8 ± 0.8

5.2 ± 0.6

DAP12KI (n = 3)

6.5 ± 1.3

4.1 ± 0.5

4.9 ± 0.9

  1. Striatal dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels in DAP12+/+and DAP12KI mice at 7 days after the last MPTP injection do not differ (P >0.05; Mann–Whitney U-test) between groups. Data represent means ± SEM for the indicated number of mice. MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
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Journal of Neuroinflammation

ISSN: 1742-2094