Figure 6

Pro-inflammatory response induced by B. burgdorferi in HSC cultures. The levels of immune mediators CCL2 (A), IL-6 (B) and IL-8 (C) in HSC cultures exposed to live B. burgdorferi spirochetes for 48 hours at a MOI of 10:1 and 50:1, respectively, and in medium controls are shown (* P <0.05, ** P <0.01). Data represent mean values and standard deviations between values of duplicate wells that were seeded for each condition for each of the two experiments set up using separate passage stocks. HSC, human Schwann cells; MOI, multiplicity of infection.