Treatment | Neurological Score | Rotarod performance (% of presurgery levels) |
---|---|---|
Sham-operated control (n = 8) | 0 | 128 ± 21 |
Repeated doses | ||
Vehicle (n = 9) | 3 (3–5) | 49 ± 18 |
Nimesulide 3 mg/kg (n = 7) | 3 (2–4) | 64 ± 13 |
Nimesulide 6 mg/kg (n = 8) | 2 (1–5) * | 89 ± 20 ** |
Nimesulide 12 mg/kg (n = 9) | 2 (1–4) ** | 84 ± 14 ** |
Single dose | ||
Vehicle, single dose (n = 7) | 3 (3–5) | 43 ± 21 |
Nimesulide 12 mg/kg, single dose (n = 8) | 3.5 (2–5) | 52 ± 19 |