Table 2 HLA-C alleles in controls and in Alzheimer's disease
From: Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity?
Allele | Homozygotes/heterozygotes/negatives (n) | Allelic frequency (%) | Unadjusted allelic odds ratio of AD (95% CI, p†) | Hardy-Weinberg equilibrium (p†) | |||
|---|---|---|---|---|---|---|---|
Controls | AD | Controls | AD | Controls | AD | ||
HLA-Cw1 | 0/9/190 | 1/14/180 | 2.3 | 4.1 | 1.85 (0.8–4.2, 0.2) | 0.7 | 0.2 |
HLA-Cw2 | 0/15/184 | 0/16/179 | 3.8 | 4.1 | 1.1 (0.5–2.2, 0.9) | 0.6 | 0.55 |
HLA-Cw4 | 1/36/162 | 1/34/160 | 9.5 | 9.2 | 1.0 (0.6–1.6, 0.9) | 0.5 | 0.6 |
HLA-Cw5 | 1/36/162 | 1/40/154 | 9.5 | 10.8 | 1.1 (0.7–1.8, 0.6) | 0.5 | 0.35 |
HLA-Cw6 | 4/31/164 | 2/31/162 | 9.8 | 9.0 | 0.9 (0.6–1.5, 0.7) | 0.09 | 0.7 |
HLA-Cw*0701 | 6/62/131 | 7/56/132 | 18.6 | 17.9 | 1.0 (0.7–1.4, 0.85) | 0.7 | 0.7 |
HLA-Cw*0702 | 1/46/152 | 9/58/128 | 12.1 | 19.5 | 1.8 (1.2–2.6, 0.0045) | 0.2 | 0.5 |
HLA-Cw*0704 | 0/8/191 | 0/3/192 | 2.0 | 0.8 | 0.4 (0.1–1.4, 0.2) | 0.8 | 0.9 |
HLA-Cw8 | 0/17/182 | 1/11/183 | 4.3 | 3.3 | 0.8 (0.4–1.6, 0.6) | 0.5 | 0.08 |
HLA-Cw9 | 0/29/170 | 0/25/170 | 7.3 | 6.4 | 0.9 (0.5–1.5, 0.7) | 0.3 | 0.3 |
HLA-Cw10 | 1/37/161 | 2/24/169 | 9.8 | 7.2 | 0.7 (0.4–1.2, 0.2) | 0.5 | 0.3 |
HLA-Cw12 | 1/11/187 | 0/8/187 | 3.3 | 2.1 | 0.6 (0.25–1.5, 0.4) | 0.08 | 0.8 |
HLA-Cw15 | 0/13/186 | 0/2/193 | 3.3 | 0.5 | 0.15 (0.03–0.7, 0.007) | 0.6 | 0.9 |
HLA-Cw16 | 0/13/186 | 1/13/181 | 3.3 | 3.8 | 1.2 (0.6–2.5, 0.7) | 0.6 | 0.2 |