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Table 1 Summary of changes in gene expression in neurotrophins, growth factors, related receptors and structural proteins

From: Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structural proteins

NEUROTROPHINS AND RECEPTORS

Th1

M/M

Th2

M55293

trkB

-3.05*

 

-2.7*

E03082

NT3

-4.15***

-2.71***

-4.73****

AI030286

brain derived neurotrophic factor

-4.19*

  

AA944973

NGFR p75 precursor

-4.26**

  

S62933

trkC, alternatively spliced

-12.13***

-7.01***

 

AF023087

NGF-inducible IA

 

2.30***

2.25*

X67108

brain derived neurotrophic factor

  

2.11*

M86742

pre-pro NT4 protein

  

-2.62**

Y07559

NT 4/5

  

-2.63**

GROWTH/MATURATION FACTORS AND RECEPTORS

AI070577

insulin-like growth factor receptor 5

3.66**

  

Z14120

platelet-derived growth factor alpha (PDGF)

2.99****

3.20***

2.23***

M32167

vascular endothelial growth factor (VEGF)

2.39*

 

3.13**

D79215

fibroblast growth factor 10

2.17*

2.59***

2.44*

M81183

insulin-like growth factor 1 (IGF-1)

-2.02**

  

E0178

TGF-alpha

-2.09**

  

M90660

insulin receptor-related receptor alpha

-2.88**

  

X12748

epidermal growth factor precursor

-3.48****

 

-2.53***

U37101

granulocyte colony stimulating factor 3 (GCSF)

 

3.24****

 

D10106

prepropeptide PDGF A chain

 

2.73***

2.31***

D64085

fibroblast growth factor 5

 

2.18*

 

M18416

early growth response 1

 

2.03*

 

X07285

basic fibroblast growth factor

 

-2.06*

 

U66470

cell growth regulatory with EF-hand domain

 

-2.07*

 

AA818970

endothelin receptor type B

  

2.70****

AB008908

fibroblast growth factor 14

  

2.64*

AF014827

c-fos induced growth factor (VEGF D)

  

2.24**

S54008

fibroblast growth factor receptor 1

  

2.01***

U02320

neuregulin 1

  

-2.17**

AA875664

GCSF signaling molecule, mitochondria-associated

  

-2.24****

M17960

insulin-like growth factor II (somatomedin A)

  

-2.95**

AI137657

platelet-derived growth factor receptor alpha

  

-3.04*

HORMONES, RECEPTORS AND RELATED MOLECULES

U94321

growth hormone secretagogue receptor

3.09*

3.13***

 

M54987

corticotropin releasing hormone

2.17*

 

2.40*

U55836

parathyroid hormone receptor

 

-2.39**

 

U25803

luteinizing hormone, beta subunit

-2.57***

-2.14**

-2.18*

M34083

prolactin receptor

-2.86***

-2.69***

 

M63296

luteinizing hormone receptor

-2.92*

  

AA799498

natriuretic peptide precursor

-3.09**

  

M27408

follicle stimuating hormone beta

-3.21*

 

-3.30*

Z33403

luteinizing hormone receptor

-3.77**

-2.80*

 

Z83757

growth hormone receptor

-4.06*

-3.81*

-4.58*

Al235978

aldosterone receptor

-6.13

  

S49003

short isoform growth hormone receptor

 

2.78*

 

U25802

luteinizing hormone, beta subunit

 

-2.79***

 

L40030

placental growth factor

 

-3.33**

 

X01454

thyroid stimulating hormone, beta subunit

 

-3.55***

 

U41183

growth hormone releasing hormone

 

-5.09*

 

M19304

prolactin receptor

 

-5.81**

 

AA893618

glucocorticoid receptor

  

-2.64*

U92469

gonadotropin-releasing hormone receptor

  

-6.06**

AA946542

prolactin-like protein D

  

-6.09*

Al180410

prolactin-like protein C

  

-6.70***

CELL ADHESION AND EXTRACELLULAR MATRIX MOLECULES

S61868

syndecan 4

2.8*

3.5**

 

AA818894

proteoglycan core peptide

2.2*

  

U56859

perlecan

-3.29*

  

S61868

syndecan 4

 

2.9*

 

U16845

neurotrimin

 

2.76*

2.68*

U09401

tenascin c

  

3.92**

U15550

tenascin c

  

2.3*

Al071104

glypican 3

  

2.04**

MI5797

nidogen (entactin)

  

-2.02*

D50568

proteoglycan, bone marrow

  

-2.12*

AJ011811

claudin 7

  

-2.12*

U35371

BIG-2

  

-2.47**

X63143

syndecan 3 (neuroglycan)

 

-2.44**

-2.35**

AA8000059

syndecan 4

  

-2.9**

Al639167

biglycan (weakly similar to bone/cartilage p.g.)

  

-3.57**

CONNEXINS

M76532

connexin 37 (CXN-37)

2.76**

  

M59936

connexin-31 (CXN-31)

2.03**

  

AF022136

connexin 40 (CXN-40)

 

-2.82*

 

NEURONAL RELATED PROTEINS

M74223

VGF nerve growth factor inducible

3.04***

3.79***

2.25***

AF031430

syntaxin 7

2.09***

  

AF056704

synapsin 3

-2.18*

 

-4.27***

S96418

activin receptor IIA

-3.41*

  

U69702

activin receptor-like kinase 7

-3.62**

  

AA818677

neurofilament, heavy polypeptide

-4.16*

  

Y16563

bassoon

-4.88*

  

X17682

MAP 2

 

3.33**

 

U22952

neuroligin

 

2.49***

 

X66840

MAP 1A

 

-2.07*

 

X06655

synaptophysin

 

-2.13***

 

X06655

synaptophysin 2

 

-2.19****

 

M64488

synaptotagmin

 

-2.20****

 

U71924

synaptotagmin XII

 

-4.56*

 

AF041246

hypocretin (orexin)

 

-5.88*

-3.87***

L20820

syntaxin 3

  

-2.43***

X95286

semaphorin 3a

  

-2.94***

RETINAL PROTEINS

X52376

rds/peripherin

 

2.09***

2.15***

Z46957

rhodopsin

 

-4.64***

-5.14**

CANCER RELATED PROTEINS

AF036760

breast cancer 1

-2.28*

-2.52*

-2.05*

U68725

deleted in colorectal cancer (rat homolog)

-4.05**

  

U32081

deleted in malignant brain tumors 1

 

-6.02***

 

M32475

carcinoembryonic antigen

  

-4.58*

BONE-RELATED PROTEINS

Y07704

Best 5 protein

39.49****

7.02**

 

Y07704

Best 5 protein

31.46***

7.41*

 

AA892798

USAG (uterine-sensitized associated gene 1)

  

-2.10*

  1. Values represent averages of fold changes from three separate experiments for each cytokine mixture compared to control. **** p < 0.01; *** p < 0.05; ** p < 0.10; * p < 0.20