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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury

Figure 7

Minozac attenuates hippocampal-dependent Y-maze behavioral impairment following TBI. Mice were subjected to TBI or sham procedure. At 3 hr and 9 hr following TBI, mice were injected with Mzc (5 mg/kg/dose) or saline diluent (VEH) via intraperitoneal injection. On days 7 through 28 of recovery, hippocampal function was assessed by alternation in the Y-maze. Treatment with Mzc prevented neurobehavioral impairment resulting from TBI. Data are expressed as mean ± S.E.M of n = 5–7 animals per group. *P < 0.05 vs TBI-VEH by ANOVA.

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Journal of Neuroinflammation

ISSN: 1742-2094