Figure 5

CC Chemokines are decreased in brains of MCP-1^-/- mice after LPS treatment. MCP-1^-/- and MCP-1^+/+ mice were injected i.p. with LPS or saline (MCP-1^+/+ mice only), and brains were removed and dissected 6 hours later. Entorhinal cortex was homogenized and supernatant assayed by Rules-Based Medicine for MIP-1α (A), MIP-1β (B), MIP-1γ (C), MCP-3 (D), eotaxin (E), and MIP-3β (F). Values are represented as mean ± SEM, n = 4–6 mice per group. ** or * represents significant difference between LPS-treated MCP-1^+/+ mice and LPS-treated MCP-1^-/- mice, **p < 0.001, *p < 0.01; # represents significant difference between saline-treated MCP-1^+/+ mice and LPS-treated MCP-1^+/+ mice, p < 0.001.