Figure 3

PGJ2 dose-dependent loss of dopaminergic neurons in the SNpc. TH (red, dopaminergic neurons) and NeuN (green, all neurons) immunostaining of SN shows a dose-dependent loss of dopaminergic neurons after microinjections with 6.7 μg or 16.7 μg of PGJ2. No dopaminergic neuronal loss was observed in the side contralateral to the injection site. Scale bar = 20 μm. The table lists TH+ cell counts in ipsilateral SNpc slices of DMSO- and PGJ2(16.7 μg)-infused mice determined as described under Methods.