Figure 9

Symptoms of motor dysfunction in mice treated with the highest PGJ2 concentration (16.7 μg). PGJ2 causes severe postural instability (A) and gait impairment (B). The curling test evaluates any asymmetry in body posture. There is a severe deviation from the vertical body axis in PGJ2 treated animals. Representative walking footprint patterns display irregular step pattern, decrease in step frequency and increase in stride length (C, graph) in the PGJ2-treated animals. The asterisk (*) identifies the values that are significantly different (p < 0.01, ANOVA, Tukey-Kramer multiple comparison test) from the control (DMSO).