Group | Geographical Region* | Subjects†| Numbers | % women | p (AD vs controls) | Median age‡ (interquartile range) | p (AD vs controls) |
---|---|---|---|---|---|---|---|
Bonn | Bonn and Mainz, Germany | Clinical AD | 259 | 61.4 |  | 71.0 (65.1–77.5) |  |
 |  | Screened controls | 232 | 56.9 | 0.31 | 67.8 (64.4–76.1) | 0.11 |
Bristol | South-West England | Autopsy AD | 200 | 45.0 |  | 80.4 (75.6–86.0) |  |
 |  | Autopsy controls | 57 | 40.4 | 0.55 | 77.9 (72.8–82.9) | 0.12 |
Nottingham | Cambridge, England | Autopsy AD | 104 | 48.1 |  | 78.7 (70.8–84.6) |  |
 |  | Autopsy controls | 107 | 34.6 | 0.051 | 72.5 (65.6–80.0) | < 0.001 |
OPTIMA | Oxford, England | Autopsy AD | 163 | 54.6 |  | 79.5 (72.4–85.2) |  |
 |  | Clinical AD | 87 | 54.0 |  | 79.1 (73.4–84.8) |  |
 |  | Screened controls | 261 | 53.6 | 0.93 | 78.9 (72.9–83.8) | 0.54 |
Oviedo | Asturias, Spain | Clinical AD | 202 | 69.8 |  | 78.4 (74.8–82.8) |  |
 |  | Screened controls | 131 | 61.8 | 0.15 | 69.7 (63.5–74.5) | < 0.001 |
Rotterdam | Rotterdam (Ommord), the Netherlands | Clinical AD | 391 | 74.9 |  | 86.6 (82.2–91.6) |  |
 |  | Screened controls | 5,111 | 57.7 | < 0.001 | 76.9 (71.7–83.0) | < 0.001 |
Santander | Cantabria, Spain | Clinical AD | 351 | 65.0 |  | 75.5 (70.8–78.9) |  |
 |  | Screened controls | 396 | 68.9 | 0.27 | 80.9 (74.7–85.6) | < 0.001 |
Totals |  | Total AD | 1,757 | 62.4 |  | 79.0 (73.0–85.2) |  |
 |  | Total controls | 6,295 | 57.7 |  | 76.9 (71.3–83.0) |  |