Figure 7
From: Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1
Trolox and minocycline effects on MCP-1 secretion. Stably transfected SH-SY5Y cells were treated for 72 hours with Trolox or 48 hours with minocycline to determine the impact of these agents on MCP-1 release. Trolox at either concentration had no significant effect of MCP-1 release in any of the SH-SY5Y cell lines in this study. Minocycline treatment resulted in a 76% decrease (p < 0.01) and 56% decrease (p < 0.001) in MCP-1 release from vector and H63D cells, respectively, but no significant effects in Wt or C282Y cells. n = 4. **, and *** indicate p < 0.01, and p < 0.001, respectively, compared to baseline MCP-1 secretion for each respective cell line.