Figure 6

Comparison of neurological dysfunction of CD59a-deficient and wild-type-mice (C57BL/6) after 30 min MCAO. The CD59-ko mice in the mixed gender group show 24 h after reperfusion (A), 48 h after reperfusion (B) and 72 h after reperfusion (C) a significant increased neurological dysfunction (p < 0,05) compared to wild-type (WT) mice. In the male gender group (D, E, F) there is only a significant difference after 48 h (E) and 72 h (F). No increase was observable in the female group (G, H, I). Statistical analysis was performed using the Mann-Whitney-U-test. A score of 0 shows no neurological dysfunctions; score 1: failure to extend right forepaw, score 2: circling to the contralateral side; score 3: loss of postural reflex and score 4: death. Number of animals: for CD59a-ko n = 27, WT n = 27. Both male and female animals were used in this study.