Figure 1

Identification of serum IL-6 as a marker of elevated ICP by antibody arrays. A. Time course of ICP in patients classified as having elevated ICP (ICP ≥ 25 mm Hg) versus that recorded in patients whose ICP remained below 20 mm Hg for the duration of the sampling period. B. Representative picture of a Ray Biosciences Cytokine array showing the immunoreactivity of interleukin family members in pooled samples (n = 7/pool) from healthy volunteers, TBI patients with elevated ICP, and TBI patients whose ICP remained below 20 mm Hg for the duration of the 5 day sampling period. C. Summary data (presented as % healthy volunteer(HV)) showing that the relative signal of IL-6 is significantly increased in patients with ICP ≥ 25 mm Hg compared to patients whose ICP remained below 20 mm Hg throughout the study period. Data is presented as mean ± SEM. ‡, significant difference by two-way ANOVA.