Figure 1

IL-1α significantly increases in rat brain after GD-induced SE. IL-1α concentrations significantly increase in the hippocampus, piriform cortex and thalamus 12 hours following GD-induced seizure activity. Concentrations of IL-1α peak at 12 hours in the piriform cortex (solid gray line), hippocampus (solid black line) and thalamus (open gray line). ^## p < 0.01 versus vehicle control in hippocampus, ** p < 0.01 versus vehicle control in piriform cortex, ^$$ p < 0.01 versus vehicle control in thalamus.