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Table 2 Oxidative stress in cPLA2α+/+ and -/- cortex after MCAO, MCAO and reperfusion, or sham surgery

From: Cytosolic phospholipase A2alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice

 

cPLA2α+/+ HE area (relative units)

cPLA2α-/- HE area (relative units)

 

Ipsilateral

Contralateral

Ipsilateral

Contralateral

 

Core

Penumbra

Core

Penumbra

Core

Penumbra

Core

Penumbra

0 h Reperfuse

45.02 ± 9.58†

38.36 ± 8.53†

6.99 ± 3.88

8.07 ± 4.70

12.76 ± 6.83

12.06 ± 5.85

4.66 ± 4.17

6.27 ± 3.83

2 h Reperfuse

33.01 ± 8.59†

30.70 ± 5.14†

8.82 ± 5.96

9.62 ± 5.95

20..09 ± 5.50

19.47 ± 6.72

6.60 ± 2.98

6.80 ± 4.09

Sham

6.32 ± 5.46

6.03 ± 5.03

5.63 ± 3.71

6.40 ± 4.65

4.11 ± 4.48

4.88 ± 5.43

3.85 ± 3.54

5.05 ± 5.67

  1. Oxidative stress was measured in the cortex of cPLA2α+/+ and -/- brains using micro-fluorescence and threshold densitometry. At the beginning of MCAO or sham surgery 10 mg/kg dihydroethedium (HE) was injected into the relative jugular vein of each mouse. The intensity of HE staining in each region is normalized for area and expressed in relative units. n = 3 mice per condition with analysis of high resolution confocal z-plane images from each mouse as described in the text. †, P < 0.01 cPLA2α+/+ compared to -/- at the same condition.
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Journal of Neuroinflammation

ISSN: 1742-2094