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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease

Figure 6

Qualitative and quantitative profile of activated astroglia in two transgenic rat models of human tauopathy. There is an approximately 25% increase in GFAP-positive astrocytes in brainstem in both transgenic lines (A - WKY TG, B - SHR TG) compared to age-matched controls (C - WKY crl, D - SHR crl). Morphological signs of astrocytic activation and hypertrophy (E) are observed in the brainstems of both transgenic rat lines. Stereological quantification (F) reveals no significant differences between WKY TG and SHR TG rats in numbers of GFAP-positive astrocytes. However, the difference in numbers of GFAP-positive astrocytes between transgenic and control rats is highly significant (two-way ANOVA, transgenic factor *** p < 0.0001). Pre-fixed frozen sections. Scale bars: 50 μm for A-D, 20 μm for E.

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Journal of Neuroinflammation

ISSN: 1742-2094