Figure 8

Ongoing demyelination/remyelination. A: Demyelination is accompanied by proliferation of Schwann cells (SC), formation of supernumerary processes, and a significant expansion of the collagenous inner endoneurial sheath. Schwann cells show no sign of degeneration. B: Inappropriately thin myelin sheaths and redundant Schwann cells are consistent with ongoing remyelination. Apart from macrophages, the endoneurium of affected nerves shows significant infiltration by plasma cells and lymphocytes (LC). A: FB = fibroblast; Scale bars = 1 μm (A), 250 nm (B).