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Table 1 Clinical EAE course and Gf lesion load

From: Gadofluorine M-enhanced MRI shows involvement of circumventricular organs in neuroinflammation

Mouse

EAE score at Gf imaging

Gf lesion load in mm3

Day of clinical onset

1

1

30.5933

10

2

3

22.0243

9

3

3

19.7933

11

4

1

17.3736

13

5

4

13.7473

6

6

2

12.2391

7

7

1

10.4559

9

8

2

9.6347

9

9

1

7.4567

9

10

2

6.3080

9

11

2

6.0699

9

12

2

4.8076

11

13

1

3.2377

11

14

1

3.0483

11

15

1

1.8621

11

16

0

1.4209

11

17

0

1.3857

-

18

3

0.9528

8

19

1

0.8987

9

20

0

0.7135

-

21

0

0.5301

-

mean (SD)

1.48 (+/-1.12)

8.31 (+/-8.34)

9.61 (+/-1.69)

  1. After detection of cranial blood-brain barrier breakdown by Gd-DTPA, 0.1 mmol/kg bodyweight Gf was applied, and MRI repeated after 24 h. The EAE score at the day of Gf imaging and the corresponding lesion volume in T1-weighted Gf-enhanced images are presented. The day of clinical onset is given as days after T cell transfer.
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Journal of Neuroinflammation

ISSN: 1742-2094