Figure 3
Regional changes in CD11b expression in spinal cord. Changes in the extent and intensity of DAB-stained CD11b expression in spinal cord of hmSOD1 rats as a function of age or disease stage. (A, B) The extent of CD11b expression relative to age-matched wild-type levels is expressed as a function of age. Linear regression slopes in the ventral horns of 0.12 ± 0.018 at the cervical-thoracic level and 0.15 ± 0.028 at the lumbar level (A). Linear regression slopes in the ventrolateral white matter are 0.05 ± 0.011 at the cervical-thoracic level and 0.069 ± 0.0107 at the lumbar level (B). (C, D) The average extent (C) and intensity (D) of CD11b expression relative to wild-type levels in spinal cord regions expressed as a function of disease stage. Bars represent average + SEM. #, significantly different compared to wild-type levels (P < 5 × 10-5, Neuman-Keuls test). *, significantly different compared to levels from only age-matched wild-type rats (P < 0.05, unpaired T test).