Figure 2From: Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease Subchronic DE Exposure Differentially Regulates Other Cytokines and Chemokines in the Midbrain. Male Fischer 344 rats were exposed to either filtered air (control, 0 μg PM/m3 DE, n = 8), 35 μg PM/m3 DE (Low, n = 8), 100 μg PM/m3 DE (Mid Low, n = 8), 311 μg PM/m3 DE (Mid High, n = 8), or 992 μg PM/m3 DE (High, n = 8) for 6 months. (A) IL-1β, (B) IL-6, and (C) MIP-1α protein levels were measured in the midbrain by ELISA. An * indicates significant difference (p < 0.05) from control animals. DE elevated IL-1β at only the highest concentration of DE, failed to affect IL-6 levels, and decreased MIP-1α expression in the midbrain.Back to article page