Figure 6

Passive immunization in APPSw mice leads to a rapid activation of the MMP2 system as well as a later activation of the MMP9 system. Panels A and B show relative gene expression analysis of the hippocampus of APPSw mice receiving control antibody for 3 months or anti-Aβ antibody for 1, 2 and 3 months. Data are shown as the average (± SEM) fold change in mRNA. Panel A shows data for the MMP2 system, panel B shows data from the MMP9 system. * indicates P < 0.05, ** indicates P < 0.01 compared to control antibody treated mice.