From: Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence
Study
Mouse model
Age (mo)
Histopathology
Cognition
Aβ
CAA
Micro-hemorrhage
Passive immunization
APPSw
19-22
↓60%
↑ 4-fold
↑ 6-fold
Improved
Active vaccination
APPSw/
NOS2-/-
12-16
↓85%
No change
↑ 10-fold
Reversed