Figure 4From: Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice LPS increases the expression of pro-inflammatory mediators whereas IGF-I attenuates their expression. Steady-state mRNA expression for IL-1β (A), TNFα (B), iNOS (C) and IL-6 (D) was quantified by real-time rtPCR. Expression was relative to GAPDH. *p < 0.05 following mean separation. n = 10 to 12 per treatmentBack to article page