Figure 5From: Curcumin is a potent modulator of microglial gene expression and migration Curcumin reduces microglial neurotoxicity on photoreceptors. (A) Phase contrast micrographs showing morphological changes of 661W photoreceptor cell cultures treated with conditioned media from BV-2 cells for 48 hours. The supernatant from control-stimulated, 20 μM curcumin-treated, 100 ng/ml LPS-treated, or 20 μM curcumin + 100 ng/ml LPS-treated cells was added to 661W photoreceptor cells, respectively. The micrographs shown are from one representative experiment out of three independent experiments with the same tendencies. (B) Apoptosis-related caspase 3/7 activation in 661W photoreceptor cells incubated with conditioned media from control-stimulated, 20 μM curcumin-treated, 100 ng/ml LPS-treated, or 20 μM curcumin + 100 ng/ml LPS-treated BV-2 cells. Results are calculated from three independent experiments performed in duplicate measurements. * p ≤ 0.05 for LPS vs. control and # p ≤ 0.05 for curcumin + LPS vs. LPS, respectively, Mann-Whitney Rank Sum test. RLU, relative luciferase units.Back to article page