Table 1 Animal cohort information
Cohort | Age (months) | Group | n | Sample Type | Analyses Performed |
|---|---|---|---|---|---|
1* | 12 | Adult | 5 | Â | Â |
| Â | 28 | Aged Intact | 8 | synaptosomes (whole hippocampus) | Morris water maze, transcriptomic analysis, qPCR |
| Â | 28 | Aged Impaired | 7 | Â | Â |
2 | 12 | Adult | 7 | Â | Â |
| Â | 26 | Aged Intact | 7 | Hippocampal subregions (CA1, CA3, DG) | Morris water maze, qPCR, immunoblotting |
| Â | 26 | Aged Impaired | 10 | Â | Â |
3* | 13 | Adult | 3 | Â | Â |
| Â | 26 | Aged Intact | 3 | Perfusion-fixed sagittal brain sections | Morris water maze, immunohistochemistry |
| Â | 26 | Aged Impaired | 3 | Â | Â |