Figure 1

Genetic deficiency of C1q does not alter fibrillar plaque pathology in 3xTg, but kinetics of plaque deposition is increased in both 3xTg and 3xTgQ-/- backcrossed to BUB. A. Representative pictures of thioflavine staining in the subiculum area of 3xTg and 3xTgQ-/- at 16 m (scale bar: 100 um). B, C. Thioflavine quantification by image analysis in the subiculum area of the 3xTg and 3xTgQ-/- (B) or the 3xTg and 3xTgBUB and 3xTgQ-/-BUB (C) at different ages. Data points are the average of n animals +/- SE at different ages. (B) 3xTg, 3xTgQ-/- at 7 m n = 8,8; at 12 m n = 11,10; at 14 m n = 3,6; at 16 m n = 9,15; at 18 m n = 3,4. (C) 3xTg, 3xTgBUB, 3xTgQ-/-BUB at 7 m n = 3,3,5; at 10 m n = 8,3,8; at 12.5 m n = 7,7,8; 18 m n = 4,5,6. *p < 0.05 (3xTg vs 3xTgBUB) using ANOVA single factor.