Figure 4

Loss of IL-17 receptor signaling results in elevated proinflammatory mediator production. Supernatants were collected from brain abscess homogenates of IL-17 receptor (IL-17R) knockout (KO) and wild-type (WT) mice (n = 5 to 8 per group) at days 7 and 14 after infection, whereupon IL-17 (a), CXCL2 (b), CCL2 (c) and CXCL9 (d) production was quantitated using multi-analyte bead arrays. Results are representative of two independent experiments and are presented as the average cytokine/chemokine concentration normalized to the total amount of protein (mean ± SD). *P < 0.05, **P < 0.01, significant differences between IL-17R KO and WT mice.