Table 1 Overview of the experimental animals used in this study

129/C57Bl/6

Non-Tg

4 NaCI, 4 PolyI:C

–

4 months

15 months (IHC)

Systemic infection in TgAD mice

3xTg-AD

5 NaCI, 7 PolyI:C

–

4 months

15 months (IHC)

C57Bl6/J

Non-Tg

5 NaCI, 5 PolyI:C

GD17

–

3 weeks (E)

Prenatal infection in non-Tg mice: longitudinal changes in cytokine and brain APP/pTau levels and cognitive performance

4 NaCI, 4 PolyI:C

GD17

–

3 months (IB/E)

5 NaCI, 5 PolyI:C

GD17

–

5 months (E)

16 NaCI, 15 PolyI:C

GD17

–

5 months (BT)

4 NaCI, 4 PolyI:C

GD17

–

6 months (IB/E)

6 NaCI, 6 PolyI:C

GD17

N*

12 months (IB)

4 NaCI, 5 PolyI:C

GD17

–

15 months (IB/E)

6 NaCI, 6 PolyI:C

GD17

–

15 months (IHC)

18 NaCI, 13 PolyI:C

GD17

–

20 months (BT)

C57Bl6/J

Non-Tg

6 NN*, 6 NP, 6N*, 7 PP

GD17

9 months

12 months (IB)

Prenatal and adult infection in non-Tg mice

10 NP, 11 PP

GD17

12 months

15 months (IHC)

6 NN, 5 NP, 4 PN, 5 PP

GD17

15 months

18 months (IHC)