The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

Table 2 Changes (percent composition) in rat plasma sphingomyelin molecular species following intraventricular infusion with propionic acid (PPA) and phosphate buffered saline (PBS)

Molecular weight	Molecular species	Base/acyl species	PBS	PPA
703	34:1	18:1/16:0	14.05 ± 1.42	4.63 ± 1.10*
733	36:0	18:0/18:0	2.63 ± 0.47	3.40 ± 1.23
731	36:1	18:1/18:0	1.54 ± 0.32	1.65 ± 0.42
761	38:0	18:0/20:0	12.91 ± 0.37	15.92 ± 0.65*
759	38:1	18:1/20:0	8.36 ± 0.56	5.77 ± 0.24*
789	40:0	18:0/22:0	9.44 ± 2.89	10.39 ± 2.03
811	42:3	18:1/24:2	51.07 ± 0.62	58.24 ± 0.68*
Total%			100	100
∑ Saturates			24.98 ± 1.33	29.72 ± 1.49*
∑ Monounsat			23.95 ± 1.53	12.05 ± 1.57*
∑ Polyunsat			51.06 ± 0.63	58.22 ± 0.68*

Values (nanomole percent by weight composition) represent means ± standard errors. Means in the same row accompanied by asterisks are significantly different between treatments at LSD = 0.05, n = 12 per treatment group. Monounsat, monounsaturated fatty acids; PBS, phosphate buffered saline solution; PPA, propionic acid; polyunsat, polyunsaturated fatty acids. Sphingomyelin molecular species were identified using a precursor ion scan of m/z 184 in ESI positive mode. The lipid components in the table are arranged based on the molecular species composition.

ISSN: 1742-2094