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Table 2 Group averaged data for mean blood pressure, somatosensory evoked potentials, P1 latencies, evoked flow velocity responses and resting LDF signal at different time points of the experiment

From: Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats

  

Baseline

30 min

60 min

120 min

180 min

240 min

270 min

Mean BP (mmHg)

SHAM

116 ± 20

120 ± 12

108 ± 20

113 ± 14

114 ± 19

108 ± 20

108 ± 20

Mean BP (mmHg)

VGX

115 ± 13

110 ± 13

112 ± 19

109 ± 14

110 ± 17

115 ± 22

115 ± 22

Mean BP (mmHg)

VGX + STIM

109 ± 10

99 ± 14

103 ± 18

100 ± 23

104 ± 29

93 ± 21

93 ± 21

Mean BP (mmHg)

SHAM LPS

123 ± 11

118 ± 14

106 ± 15**

104 ± 10**

90 ± 12s

90 ± 18s

90 ± 18s

Mean BP (mmHg)

VGX LPS

117 ± 9

109 ± 17

91 ± 17s

94 ± 18***

101 ± 13*

97 ± 10**

97 ± 10**

Mean BP (mmHg)

VGX LPS + STIM

119 ± 13

114 ± 12

94 ± 17*

92 ± 7***

86 ± 20 s

90 ± 14***

90 ± 14***

SEP (μV)

SHAM

13 ± 7

15 ± 6

14 ± 4

15 ± 5

14 ± 5

15 ± 5

14 ± 5

SEP (μV)

VGX

15 ± 9

15 ± 8

16 ± 9

16 ± 9

15 ± 6

15 ± 6

16 ± 8

SEP (μV)

VGX + STIM

15 ± 9

13 ± 4

14 ± 4

12 ± 5

11 ± 5

13 ± 3

15 ± 8

SEP (μV)

SHAM LPS

17 ± 5

16 ± 6

15 ± 6

12 ± 6

11 ± 5

11 ± 4**

10 ± 6**

SEP (μV)

VGX LPS

18 ± 6

15 ± 4

14 ± 5

12 ± 4**

11 ± 7**

10 ± 5**

8 ± 5***

SEP (μV)

VGX LPS + STIM

18 ± 8

18 ± 9

19 ± 9

16 ± 5

16 ± 5

14 ± 4

15 ± 7

P1 latency (ms)

SHAM

10.8 ± 1

11.1 ± 1

11.2 ± 1

11.1 ± 1

11.3 ± 1

11.4 ± 1

11.7 ± 2

P1 latency (ms)

VGX

10 ± 0.6

10 ± 0.5

10 ± 0.6

10 ± 0.4

10 ± 0.4

10 ± 0.4

10.1 ± 0.5

P1 latency (ms)

VGX + STIM

10.2 ± 1

10.4 ± 1

10.5 ± 1

10.3 ± 1

10 ± 0.7

10 ± 0.7

10 ± 0.9

P1 latency (ms)

SHAM LPS

10 ± 0.5

10 ± 0.6

10 ± 0.5

10 ± 0.6

10 ± 0.6

10.3 ± 0.7

10.4 ± 1

P1 latency (ms)

VGX LPS

10 ± 0.8

10.4 ± 1

10.4 ± 0.8

10.6 ± 0.4

10.6 ± 0.7

11 ± 0.9

11 ± 1

P1 latency (ms)

VGX LPS + STIM

10 ± 0.4

10 ± 0.3

10 ± 0.3

10 ± 0.3

10 ± 0.4

10.2 ± 0.4

10 ± 0.4

EFVR (%)

SHAM

34 ± 10

26 ± 7

30 ± 11

31 ± 15

29 ± 14

31 ± 12

28 ± 7

EFVR (%)

VGX

23 ± 13

23 ± 15

21 ± 11

24 ± 15

24 ± 6

23 ± 7

24 ± 11

EFVR (%)

VGX + STIM

33 ± 13

35 ± 18

36 ± 13

29 ± 17

31 ± 18

32 ± 25

38 ± 14

EFVR (%)

SHAM LPS

27 ± 11

29 ± 11

26 ± 8

18 ± 10

18 ± 16

14 ± 11*

12 ± 8*

EFVR (%)

VGX LPS

34 ± 9

36 ± 7

26 ± 5

19 ± 9**

17 ± 16**

7 ± 5s

7 ± 4s

EFVR (%)

VGX LPS + STIM

34 ± 8

35 ± 11

32 ± 9

31 ± 13

28 ± 12

29 ± 13

28 ± 13

Resting LDF (U)

SHAM

163 ± 66

152 ± 71

140 ± 62

145 ± 82

142 ± 75

145 ± 71

139 ± 72

Resting LDF (U)

VGX

233 ± 78

219 ± 106

211 ± 88

199 ± 84

203 ± 101

213 ± 111

201 ± 107

Resting LDF (U)

VGX + STIM

224 ± 92

231 ± 75

232 ± 60

239 ± 30

193 ± 33

196 ± 49

186 ± 57

Resting LDF (U)

SHAM LPS

202 ± 56

198 ± 64

186 ± 64

189 ± 72

204 ± 96

215 ± 104

250 ± 105

Resting LDF (U)

VGX LPS

160 ± 70

141 ± 58

151 ± 62

157 ± 57

192 ± 60

198 ± 67

196 ± 59

Resting LDF (U)

VGX LPS + STIM

173 ± 68

165 ± 69

177 ± 69

185 ± 65

227 ± 35

231 ± 56

227 ± 52

  1. Data are given as the mean ± standard deviation (SD) together with statistical differences. Significance is given as: *, P < 0.05; **, P < 0.01; ***, P < 0.001; s, P < 0.0001 compared to baseline. BP, blood pressure; EFVR, evoked flow velocity responses; LDF, laser Doppler flowmetry; LPS, lipopolysaccharide; SEP, somatosensory evoked potentials; SHAM, sham surgery; VGX, bilateral vagotomy; VGX + STIM, bilateral vagotomy and distal vagus nerve stimulation.
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Journal of Neuroinflammation

ISSN: 1742-2094