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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus

Figure 8

Representative gels (inset) or temporal changes in Bcl-2, Bax or cytochrome c relative to β-actin protein detected in the cytosolic or relative to cytochrome c oxidase subunit IV (COX-IV) in the mitochondrial fraction of samples collected from the CA3 subfield of the hippocampus 24 h after microinjection of kainic acid (KA) (0.5 nmol) or PBS into the left hippocampal CA3 subfield, in animals that received pretreatment with application into the bilateral CA3 subfield of 3% dimethyl sulfoxide (DMSO), 6 nmol rosiglitazone (RGZ) or 500 ng GW9662. (A) Cytosolic fraction and (B) mitochondrial fraction of samples. Values are mean ± standard error of the mean (SEM) of quadruplicate analyses from six animals per experimental group. *P < 0.05 versus sham-control group, +P < 0.05 versus sham-control, DMSO + KA or GW9662 + KA group, and #P < 0.05 versus sham-control, DMSO + KA or RGZ + KA group in the Scheffé multiple-range test.

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Journal of Neuroinflammation

ISSN: 1742-2094