From: Complement is dispensable for neurodegeneration in Niemann-Pick disease type C
Npc1 -/- & ____ | Function/Pathway | Micea(n) | Change in PN loss | Change in microglia | Change in %CD68b | Ref. |
---|---|---|---|---|---|---|
C1qa -/- | Complement | 11 | No | No | P = 0.49 | Figure 5B |
C3 -/- | Complement | 7 | No | No | P = 0.88 | Â |
Mmp12 -/- | ECM degradation | 4 | No | No | P = 0.95 | Â |
Bcl2l11(Bim) -/- | Apoptosis | 4 | No | No | P = 0.17 | Â |
Tlr7 -/- | Toll-like receptor | 3 | No | No | n/a | Â |
Unc93b1 3d/3d | Toll-like receptor | 3 | No | No | n/a | Â |
Pcp2-tTA; TetO-Npc1YFP | Purkinje neuron (PN) rescue | 32 | Yes | Yes | P = 0.0057 |