Selective targeting of microglia by quantum dots

Table 1 Microglial release of cytokines

	TNFα	IL-1α	IL-1β	IL-6	KC	RANTES	G-CSF	MCP-1	MIP-1α	MIP-1β	IP-10
Ctrl	0.9 ± 0.5	ND	ND	2.3 ± 1.7	1.4 ± 0.8	2.3 ± 1.7	ND	ND	2.4 ± .9	3.8 ± 1.5	54.6 ± 35.3
(n = 3)
Qdots	0.3 ± 0.1	ND	ND	ND	0.5 ± 0.1	1.2 ± 0.01	ND	ND	1.5 ± 1.0	3.2 ± 3.0	17.6 ± 9.8
(n = 2)
LPS	226.5 ± 9.4	6.3 ± 3.2	1.7 ± 0.8	471.9 ± 34.6	345.5 ± 21.0	391.8 ± 19.0	53.9 ± 9.3	12.1 ± 7.2	592.7 ± 76.3	500.0 ± 23	189.8 ± 14.2
(n = 3)
LPS+	217.1 ± 47.4	9.6 ± 6.9	2.6 ± 2.1	533 ± 197.5	363.5 ± 89.4	394.5 ± 84.2	49.4 ± 5.3	20.7 ± 17.9	637.3 ± 263.5	519.2 ± 169.0	196.0 ± 53.9
Qdots (n = 2)

Cytokines (pg/ml) released by primary microglia treated with vehicle, QD, LPS, or LPS + QD (mean ± SEM). n, number of wells per condition. ND not detected, G-CSF granulocyte colony-stimulating factor, IP-10 10 kDa interferon-gamma-induced protein, KC, keratinocyte chemoattractant, MCP-1 monocyte chemotactic protein-1, MIP-1α macrophage inflammatory protein 1 alpha, MIP-1β macrophage inflammatory protein 1 beta, RANTES, regulated upon activation. The following cytokines were undetectable in all conditions: VEGF, IFNγ, and IL-10

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