Figure 5From: TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation Morris water maze test. (A). Visible platform training. There was no significant group difference in average swim velocity or escape latency to the platform (B). Hidden platform training. aCSF-vehicle, aCSF-DT and LPS-DT groups improved their daily performance during the acquisition phase of the Morris water maze task, whereas LPS-vehicle rats showed an impaired learning profile. The average escape latency of LPS-vehicle rats was significantly higher than that of aCSF-vehicle animals on the second (*p < 0.05) and third day (***p < 0.001). The average escape latency of LPS-DT rats did not significantly differ from aCSF-vehicle rats, and was significantly lower than that of LPS-vehicle animals on the third day of training (## p < 0.01). (C). Probe test. aCSF-vehicle, aCSF-DT and LPS-DT groups spent a significantly higher percentage of time in the target quadrant than the other quadrants (***p < 0.001 vs. other quadrants) whereas LPS-vehicle rats did not.Back to article page