Microarray analysis | Real-time PCR | ||||||
---|---|---|---|---|---|---|---|
Symbol | Probeset | FC (PG) | P * (P G) | FC (SG) | P * (S G) | RQ (age+OVX) | P (age+OVX) |
Macrophage-associated genes | |||||||
Phagocytic and scavenger receptors | |||||||
CD11b b | 205786_s_at | 1.341 | 0.918 | 1.145 | 0.832 | 2.778 | < 0.001 |
CD18 b | 1555349_a_at | 2.808 a | 0.697 | 2.331 a | 0.629 | 2.164 | < 0.001 |
FCGR2b | 210889_s_at | 1.020 | 1.000 | 1.228 | 0.746 | 2.488 | < 0.001 |
CD36 | 228766_at | 0.670 a | 0.942 | 0.812 | 0.793 | 0.440 | < 0.001 |
RAGE | 217046_s_at | 1.000 | 1.000 | 0.991 | 0.960 | 1.066 | |
Recognition receptors | |||||||
CD14 | 201743_at | 5.134 a | 0.697 | 2.817 a | 0.629 | 1.174 | |
CD40 b | 205153_s_at | 1.025 | 0.877 | 0.967 | 0.881 | 1.481 | 0.054 |
CD45 b | 212588_at | 1.903 a | 0.918 | 1.152 | 0.938 | 1.799 | < 0.001 |
CD86 b | 205685_at | 1.466 | 0.697 | 1.094 | 0.709 | 1.782 | < 0.001 |
TLR2 | 204924_at | 1.832 a | 0.781 | 1.035 | 1.000 | 1.015 | |
TLR4 | 221060_s_at | 1.152 | 1.000 | 1.634 a | 0.629 | 1.512 | < 0.001 |
TLR9 | 223903_at | 1.182 | 0.629 | 1.907 | 0.008 | ||
CD74 b | 1567628_at | 2.232 a | 0.697 | 1.631 a | 0.689 | 2.255 | 0.047 |
Signaling | |||||||
NOS2 | 212531_at | 0.965 | 1.000 | 1.002 | 1.000 | 1.041 | |
IRF7 | 208436_s_at | 1.047 | 1.000 | 1.341 | 0.629 | 4.748 | < 0.001 |
IRF9 | 203882_at | 1.105 | 1.000 | 1.242 | 0.629 | 1.746 | < 0.001 |
Regulatory genes for microglia reactivity | |||||||
Microglial receptors | |||||||
CD200R | 1552875_a_at | 0.990 | 0.942 | 0.990 | 0.763 | 0.722 | < 0.001 |
CX3CR1 | 1568934_at | 0.557 a | 0.967 | 0.960 | 1.000 | 1.341 | 0.005 |
Neuronal ligand | |||||||
CD200 | 209582_s_at | 0.886 | 1.000 | 0.497 a | 0.629 | 0.829 | 0.019 |
SIRPA | 202897_at | 0.799 | 0.877 | 0.908 | 0.750 | 0.987 | |
CX3CL1 | 823_at | 0.462 a | 0.697 | 0.575 a | 0.629 | 0.754 | < 0.001 |
Complement and cytokine genes | |||||||
Complement | |||||||
C1q | 202953_at | 4.364 a | 0.697 | 2.319 a | 0.629 | 1.654 | < 0.001 |
C1-INH | 200986_at | 1.419 | 0.877 | 1.723 a | 0.629 | 1.553 | 0.009 |
C3 | 217767_at | 1.577 a | 0.942 | 1.246 | 0.842 | 5.126 | < 0.001 |
Chemokine and cytokines | |||||||
CCL2 | 216598_s_at | 1.976 a | 0.942 | 2.492 a | 0.629 | 2.114 | 0.014 |
IL1b | 205067_at | 0.669 | 0.984 | 0.743 | 0.763 | 1.238 | |
IL6 | 205207_at | 0.594 a | 0.907 | 0.748 | 0.709 | 0.728 | |
TGFb1 | 203085_s_at | 1.812 a | 0.781 | 1.988 a | 0.629 | 1.347 | < 0.001 |
TNF | 207113_s_at | 1.345 |