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Table 1 Digoxin and prazosin unbound protein fraction in plasma (f u,plasma ) and brain tissue (f u,brain )

From: Susceptibility of juvenile and adult blood–brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity

Compounds

fu,plasma

fu,brain

fu,brain/fu,plasmaratio

 Prazosin

0.204 ± 0.001

0.071 ± 0.004

0.349

 Digoxin

0.379 ± 0.001

0.218 ± 0.027

0.576

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Journal of Neuroinflammation

ISSN: 1742-2094