Figure 6
From: The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
The NALP3 inflammasome participates in tumor necrosis factor and chemokine (C-C motif) ligand (CCL)3 mRNA upregualtion in PrP106-126-stimulated microglia. Real-time quantitative PCR analysis of the mRNA level of TNF-α and CCL3 in BV2 cells treated for 12 hours with PrP106-126 after small interfering (si)RNA-mediated silencing of (a) NALP3 and (b) ASC siRNA silencing. Data represent the mean ± SD of triplicate samples from one of three independent experiments. *P < 0.05, significantly different from PrP106-126 treated cells.