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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin

Figure 1

CRH augments VEGF release from IgE/anti-IgE-stimulated human mast cells, and increases FcεRI gene expression. (A) VEGF secretion from LAD2 cells was measured after pretreatment with CRH 10 μmol/l for 24 hours, followed by 2 hours of incubation with IgE 1 microgram/μl in response to anti-IgE 10 μg/ml. (B) FcεRI mRNA expression was assessed after stimulation of hCBMCs with CRH (0.1, 1, 10 μmol/l) for 6 hours. For all experiments, n = 5; *p < 0.05, **p < 0.01, ***p < 0.001 compared with control.

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Journal of Neuroinflammation

ISSN: 1742-2094