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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin

Figure 2

Mitochondria augment VEGF release from IgE/anti-IgE-stimulated human mast cells, and inhibition by luteolin. (A) VEGF secretion from hCBMCs was measured after pretreatment with IgE 1 microgram/μl for 2 hours and then incubating with mitochondria (0.1 and 10 microgram/μl) and anti-IgE (10 microgram/μl) for 24 hours. Pretreatment with luteolin 100 μmol/l for 30 minutes completely inhibited VEGF release and dropped it even below basal levels. For all experiments, n = 5; *p < 0.05, **p < 0.01, ***p < 0.001 compared with control.

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Journal of Neuroinflammation

ISSN: 1742-2094