GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders

Table 1 Levels of the measured parameters in plasma of autistic patients compared to control

Parameter	Group	N	Mean ± SD	Percent change	P-value
GABA (μmol/l)	Control	19	0.53 ± 0.05	100.00	0.001
GABA (μmol/l)	Autistic	20	0.83 ± 0.12	157.71	0.001
Glutamate (μmol/l)	Control	19	111.91 ± 4.63	100.00	0.001
Glutamate (μmol/l)	Autistic	20	152.80 ± 6.47	136.54	0.001
Glutamate/GABA ratio	Control	19	214.72 ± 22.26	100.00	0.003
Glutamate/GABA ratio	Autistic	20	188.12 ± 30.11	87.61	0.003
IL-6	Control	19	363.49 ± 22.88	100.00	0.001
IL-6	Autistic	20	273.87 ± 32.49	75.34	0.001
TNF-α	Control	19	346.23 ± 24.95	100.00	0.001
TNF-α	Autistic	20	252.35 ± 63.60	72.89	0.001
INF-γ (ng/ml)	Control	19	50.85 ± 5.71	100.00	0.001
INF-γ (ng/ml)	Autistic	20	85.33 ± 9.06	167.80	0.001
IFI16 (ng/ml)	Control	19	1.91 ± 0.60	100.00	0.001
IFI16 (ng/ml)	Autistic	20	3.11 ± 1.01	162.49	0.001

Table 1 describes the independent samples t-test between the control and autistic groups for all parameters.

ISSN: 1742-2094