Table 2 Baseline parameter comparisons of low and high groups
|  | Low group (baseline CSF neopterin <21, n = 33) | High group (baseline CSF neopterin >21, n = 11) | P value |
|---|---|---|---|
Age (years) | 37 (30 to 46) | 36 (28 to 47) | 0.87 |
Days post-transmission | 136 (84 to 189) | 70 (34 to 191) | 0.23 |
Blood CD4+ T-cells (cells/μL) | 601 (444 to 750) | 308 (275 to 389) | <0.001 |
Blood CD8+ T-cells (cells/μL) | 993 (692 to 1,269) | 1,037 (725 to 1,707) | 0.58 |
Plasma HIV RNA (log10 copies/mL) | 4.2 (3.8 to 4.8) | 5.3 (4.4 to 5.9) | 0.02 |
CSF HIV RNA (log10 copies/mL) | 2.5 (1.7 to 3.2) | 3.7 (2.8 to 4.9) | 0.006 |
CSF:plasma HIV RNA ratio (log10) | −1.8 (−2.2 to −1.2) | −1.4 (−2.3 to −0.5) | 0.37 |
CSF WBC count | 6 (2.5 to 9.5) | 10 (1 to 11) | 0.61 |
Plasma neopterin (nmol/L) | 13.9 (10.2 to 18.2) | 21.5 (18.3 to 37.5) | 0.006 |
CSF neopterin (nmol/L) | 8.5 (5.8 to 11.8) | 39.1 (29.2 to 56.6) | <0.001 |
CSF:plasma neopterin ratio | 0.66 (0.42 to 0.8) | 1.8 (1.3 to 2.6) | <0.001 |
CSF:plasma albumin ratio | 5.4 (4.3 to 6.4) | 7.4 (4.6 to 10.9) | 0.06 |