Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals

Table 3 Comparison of IGFs and related proteins in plasma and CSF in subjects with or without neurocognitive impairment

	Factors	All subjects	NC impaired	NC unimpaired	P value
	Factors	( n = 107)	( n = 58)	( n = 49)	P value
Plasma	IGF1 (mean ± SD, ng/ml)	192.5 ± 55.3	186.0 ± 63.28	200.1 ± 43.7	0.127
	IGF2 (mean ± SD, ng/ml)	703.3 ± 165.2	686.1 ± 170.5	723.3 ± 158.3	0.520
	log IGFBP1 (mean ± SD, ng/ml)^a	1.43 ± 0.74	1.45 ± 0.85	1.40 ± 0.59	0.797
	IGFBP2 - median (IQR)	33.97	38.59	26.00	0.346
	IGFBP2 - median (IQR)	(14.44 to 51.76)	(16.13 to 47.72)	(6.54 to 54.39)	0.346
	log IGF2R (mean ± SD, ng/ml)^a	4.51 ± 0.88	4.47 ± 0.97	4.56 ± 0.77	0.716
CSF	IGF1 - median (IQR)	1.11 (0.92 to 1.48)	1.11 (0.88 to 1.48)	1.13 (0.92 to 1.51)	0.821
	log IGF2 (mean ± SD, ng/ml)^a	3.70 ± 0.17	3.72 ± 0.17	3.68 ± 0.17	0.345
	IGFBP1 - median (IQR)	0.48 (0.35 to 0.77)	0.50 (0.37 to 0.75)	0.47 (0.33 to 1.59)	0.880
	log IGFBP2 (mean ± SD, ng/ml)^a	4.35 ± 0.37	4.35 ± 0.32	4.36 ± 0.41	0.986
	IGF2R^0.5 (mean ± SD, ng/ml)^b	2.56 ± 0.84	2.51 ± 0.87	2.62 ± 0.80	0.498

^aPlasma IGFBP1, plasma IGF2R, CSF IGF2 and CSF IGFBP2 were transformed with natural logarithms; ^bCSF IGF2R was square root transformed. IQR, interquartile range.

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