Induction of the type I interferon response in neurological forms of Gaucher disease

Table 1 Top ten up-regulated genes

Gene symbol	Gene name	Fold change (−/− vs. +/−)	p value	Reference^a
Cxcl10^* (IP-10)	Chemokine (C-X-C motif) ligand 10	86.3	<0.001	[68]
Usp18^*	Ubiquitin specific peptidase 18	79.2	<0.005	[30]
Ifit1^*	Interferon-induced protein with tetratricopeptide repeats 1	75.2	<0.001	[69]
Irf7^*	Interferon regulatory factor 7	71.7	<0.005	[30]
Cxcl13^*	Chemokine (C-X-C motif) ligand 13	67.2	<0.05	[70]
Gpnmb	Glycoprotein (Transmembrane) Nmb	63.0	<0.005
Lcn2	Lipcalin 2	60.1	<0.005
Oasl2^*	2′-5′ oligoadenylate synthetase-like 2	56.0	<0.005	[30]
Tgm1	Transglutaminase 1, K polypeptide	46.5	<0.005
Ifit3^*	Interferon-induced protein with tetratricopeptide repeats 3	42.1	<0.001	[69]

Type I IFN-induced genes are indicated by asterisks
^aReferences refer to studies demonstrating that these genes are induced by type I IFN

ISSN: 1742-2094