Table 3 Comparison of gene arrays for NPC1, Sandhoff, and nGD

Tissue

Spinal cord

Brain

VPM/VPL

Age/disease severity

4 months old (late-symptomatic stage)

20 to 80 days old (asymptomatic-, early-, and late-symptomatic stages)

14 days old (asymptomatic stage)

Analysis cut-off

2-fold

1.5-fold

1.5-fold

Number of up-regulated genes

58

112

907

Number (and percent) of up-regulated genes common to nGD

32 (55.2 %)

88 (78.5 %)

Number (and percent) of IFN-related genes among the up-regulated genes

1 (1.7 %)

9 (8 %)

49 (5.4 %)

Percentage of IFN-related gene out of total of 145 IFN-related genes

0.70 %

6.20 %

33.80 %