From: Inflammatory profile in LRRK2-associated prodromal and clinical PD
 | Female N = 152 | Male N = 96 | Female | Male | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Serum Marker | NMCLRRK2 N = 63 | NMCLRRK2 Prodromal N = 18 | CON N = 89 | NMCLRRK2 N = 52 | NMCLRRK2 Prodromal N = 15 | CON N = 44 | p value NMCLRRK2 CON | p value NMCLRRK2 Prodromal CON | p value NMCLRRK2 CON | p value NMCLRRK2 Prodromal CON |
Alpha fetoprotein ng/ml | 0.59 0.06–3.53 | 0.58 0.19–2.28 | 0.76 0.07–6.94 | 0.89 0.14–2.47 | 0.93 0.31–2.47 | 0.95 0.33–3.52 | 0.004 | 0.051 | 0.068 | 0.281 |
BDNF (Brain-derived neurotrophic factor) ng/ml | 17.50 3.30–41.70 | 26.20 3.85–41.70 | 19.70 2.92–41.70 | 13.00 1.40–40.50 | 6.98 1.74–36.60 | 17.05 2.88–45.10 | 0.376 | 0.258 | 0.026 | 0.128 |
ENA-78 (Epithelial-derived neutrophil-activating peptide 78) ng/ml | 2.14 0.38–5.77 | 2.26 0.38–5.76 | 2.03 0.48–7.70 | 1.63 0.46–5.98 | 1.71 0.46–3.75 | 1.54 0.19–4.77 | 0.610 | 0.811 | 0.016 | 0.203 |
FABP (Fatty-acid-binding protein) ng/ml | 2.87 0.88–14.40 | 3.03 1.62–7.99 | 2.87 0.97–12.00 | 3.71 2.05–17.80 | 3.80 2.44–17.80 | 4.04 1.44–11.50 | <0.001 | <0.001 | <0.001 | 0.096 |
GH (Growth hormone) ng/ml | 2.18 0.08–35.60 | 3.16 0.08–30.30 | 1.61 0.11–29.60 | 0.35 0.06–6.28 | 0.36 0.06–1.37 | 0.34 0.07–24.50 | 0.109 | 0.266 | 0.175 | 0.270 |
ICAM-1 (Intercellular adhesion molecule 1) ng/ml | 156.00 103.00–317.00 | 157.50 121.00–224.00 | 160.00 80.00–288.00 | 154.50 99.10–329.00 | 155.00 99.10–329.00 | 150.50 83.40–232.00 | 0.839 | 0.930 | 0.085 | 0.632 |
IL-1-beta pg/ml | 1.76 0.71–4.41 | 2.07 0.94–4.41 | 1.84 0.56–4.10 | 2.22 0.78–4.68 | 2.46 0.78–3.67 | 2.17 1.02–3.30 | 0.427 | 0.072 | 0.471 | 0.158 |
IL-4 pg/ml | 15.90 4.89–30.00 | 15.80 9.01–26.80 | 15.10 6.73–31.50 | 13.10 5.02–23.60 | 14.82 8.19–20.90 | 14.00 5.02–27.00 | 0.562 | 0.458 | 0.333 | 0.692 |
IL-6 pg/ml | 3.65 1.05–10.60 | 3.71 2.11–8.77 | 3.65 1.27–99.10 | 4.42 2.50–17.50 | 4.87 2.50–10.30 | 4.71 2.17–9.57 | 0.062 | 0.039 | 0.246 | 0.223 |
IL-8 pg/ml | 10.70 4.89–30.00 | 10.85 3.17–84.00 | 11.60 3.60–60.30 | 10.30 2.36–39.20 | 10.50 6.53–39.20 | 10.75 2.65–77.50 | <0.001 | 0.039 | 0.029 | 0.288 |
IL-10 pg/ml | 3.57 1.78–32.80 | 3.61 1.80–9.69 | 3.26 1.78–7.70 | 3.44 1.78–9.96 | 3.49 1.78–9.96 | 3.26 1.78–7.59 | 0.910 | 0.809 | 0.820 | 0.932 |
IL-12-p40 ng/ml | 0.24 0.07–0.77 | 0.24 0.07–0.77 | 0.24 0.07–0.69 | 0.19 0.08–0.38 | 0.22 0.09–0.38 | 0.16 0.07–0.36 | 0.010 | 0.001 | 0.294 | 0.432 |
IL-16 pg/ml | 497.00 177.00–752.00 | 532.50 342.00–735.00 | 551.00 239.00–1370.00 | 524.00 261.00–1060.00 | 549.00 419.00–815.00 | 520.00 268.00–760.00 | 0.007 | 0.197 | 0.100 | 0.281 |
IL-18 pg/ml | 288.00 110.00–15000.00 | 290.00 152.00–440.00 | 282.00 140.00–3360.00 | 313.00 165.00–872.00 | 333.00 186.00–872.00 | 306.00 141.00–681.00 | 0.551 | 0.828 | 0.083 | 0.084 |
Leptin ng/ml | 17.10 1.90–90.60 | 24.25 7.16–44.70 | 15.70 2.10–123.00 | 7.03 1.48–38.40 | 9.90 3.60–31.90 | 7.06 1.14–32.50 | 0.674 | 0.035 | 0.314 | 0.475 |
MCP-1 (Monocyte chemotactic protein 1) pg/ml | 333.00 40.80–854.00 | 325.50 199.00–635.00 | 342.00 113.00–844.00 | 329.50 12.20–740.00 | 292.00 12.20–667.00 | 323.50 120.00–916.00 | 0.246 | 0.631 | 0.148 | 0.290 |
MDC (Macrophage-derived chemokine) pg/ml | 452.00 216.00–981.00 | 539.50 216.00–981.00 | 474.00 93.80–1800.00 | 464.00 217.00–855.00 | 423.00 261.00–774.00 | 483.00 188.00–950.00 | 0.514 | 0.504 | 0.249 | 0.692 |
MIP-1-beta (Macrophage inflammatory protein-1-beta) pg/ml | 183.00 61.50–720.00 | 240.00 61.50–436.00 | 215.00 62.20–955.00 | 167.00 77.20–736.00 | 220.00 77.20–736.00 | 208.00 69.40–2520.00 | 0.607 | 0.302 | 0.240 | 0.604 |
MMP-3 (Matrix-metallo-proteinase-3) ng/ml | 10.70 4.04–66.60 | 12.70 6.32–66.60 | 12.30 6.08–92.90 | 21.35 11.30–46.80 | 21.00 11.90–45.20 | 23.55 9.61–53.80 | <0.001 | 0.055 | 0.418 | 0.600 |
MMP-9 (Matrix-metallo-proteinase-9) ng/ml | 20.40 10.80–40.90 | 22.45 11.90–40.90 | 19.60 12.60–61.60 | 25.70 16.10–36.10 | 25.30 16.10–36.10 | 25.40 16.10–37.80 | 0.009 | 0.007 | 0.762 | 0.931 |
SCF (Stem cell factor) pg/ml | 264.00 154.00–520.00 | 263.00 193.00–404.00 | 277.00 117.00–614.00 | 280.00 145.00–635.00 | 299.00 190.00–458.00 | 279.00 127.00–494.00 | 0.013 | 0.037 | 0.076 | 0.166 |
TF (Tissue factor) ng/ml | 0.24 0.12–0.57 | 0.26 0.15–0.57 | 0.24 0.07–0.53 | 0.29 0.13–1.67 | 0.32 0.16–0.48 | 0.30 0.15–0.43 | 0.004 | 0.004 | 0.514 | 0.464 |
TNF-alpha (Tumor necrosis factor alpha) pg/ml | 54.30 27.60–106.00 | 55.75 41.60–106.00 | 60.00 27.60–110.00 | 74.60 33.00–103.00 | 78.30 38.40–98.60 | 69.30 49.80–105.00 | 0.752 | 0.652 | 0.149 | 0.262 |
TPO (Thrombopoetin) pg/ml | 2.08 0.19–3.86 | 2.24 0.22–3.49 | 2.37 0.56–4.48 | 1.62 0.55–4.18 | 2.05 0.55–3.87 | 2.37 0.59–3.64 | 0.175 | 0.204 | 0.082 | 0.115 |