Fig. 3
From: Fractalkine suppression during hepatic encephalopathy promotes neuroinflammation in mice
Soluble fractalkine ICV infusion improved outcomes of AOM-treated mice. a Neurological decline in AOM-treated mice infused ICV with either saline or soluble fractalkine (sFKN). The neurological score is a summation of assessments for five reflexes and ataxia that indicate a worse neurological state with a lower score, which is displayed in hours post AOM injection. b Time to coma in hours for AOM-treated mice infused with either saline or sFKN. c Hematoxylin and eosin staining in liver sections from vehicle or AOM-treated mice infused ICV with saline or sFKN. d Total serum bilirubin concentrations in vehicle or AOM-treated mice infused with saline or sFKN. e Serum ALT concentrations in vehicle or AOM-treated mice infused ICV with saline or sFKN. For neurological score and time to coma analyses, *p < 0.05 compared to AOM-treated mice infused with saline. For ALT and bilirubin assays, *p < 0.05 compared to vehicle-treated ICV saline mice, # p < 0.05 compared to AOM-treated ICV saline mice. n = 4 for all analyses