Fig. 6

Gene set enrichment analysis of transcriptomic changes. The schematic histogram shows a typical expression profile of the transcriptomic changes after treatment (y-axis = fold changes; x-axis = one vertical line (stick) represents one transcript; red, up; blue, down). mRNA transcripts (sticks) and gene sets (names) that are high in IFNAR^−/− astrocytes, IFNαB/D and supernatant-treated WT astrocytes, compared to WT astrocytes, are marked as red. Genes and gene sets that are downregulated or have a negative normalized enrichment score (NES), respectively, compared to WT astrocytes are blue. pval nominal p value, adj.pval Benjamini-Hochberg adjusted p value. An adj.pval <0.05 is regarded significant